Liposomes, from physical structure to therapeutic applications

Cover of: Liposomes, from physical structure to therapeutic applications |

Published by Elsevier/North-Holland Biomedical Press, sole distributors for the U.S.A. and Canada, Elsevier North-Holland in Amsterdam, New York, New York .

Written in English

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  • Liposomes.,
  • Membranes (Biology),
  • Drug carriers (Pharmacy),
  • Biological models.,
  • Liposomes.,
  • Liposomes -- Administration and dosage.

Edition Notes

Includes bibliographies and index.

Book details

Statementeditor, C.G. Knight.
SeriesResearch monographs in cell and tissue physiology ;, v. 7
ContributionsKnight, C. G.
LC ClassificationsQH601 .L57
The Physical Object
Paginationxix, 497 p. :
Number of Pages497
ID Numbers
Open LibraryOL4269211M
ISBN 100444803203
LC Control Number81015298

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Liposomes: From Physics to Applications 1st Edition (which are invisible to the immune system and have shown encouraging results in cancer therapy). Rather than being presented in a "catalog" style, the data are logically explained, and fundamental models and mechanisms are reviewed and proposed.

Cited by: Liposomes, from physical structure to therapeutic applications. Amsterdam ; New York: Elsevier/North-Holland Biomedical Press ; New York: sole distributors for the U.S.A.

and Canada, Elsevier North-Holland, (OCoLC) Document Type: Book: All Authors /. Currently, the major areas of progress are in delivery of anti-fungal agents by conventional liposomes or lipid-based carriers and systemic anticancer therapy using long-circulating liposomes. The future applications as characterized by the direction of present day research is in specific targeting and delivery of informational molecules such.English, Book, Illustrated edition: Liposomes, from physical structure to therapeutic applications / editor, C.G.

Knight. Semantic Scholar extracted view of "Liposomes: from physical structure to therapeutic applications: C.G. Knight (Ed.), Elsevier/North-Holland Biomedical Press.

The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 's by A.D. Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several crises.

Applications of liposomes Although they are composed from natural substances liposomes are no exception. They are rapidly cleared from the circulation by the macrophages which are located mainly in the liver, spleen, and bone marrow.

Modes of liposome action Liposomes as drug delivery systems can offer several advantages over conventionalFile Size: KB. Other medical applications of liposomes Metal detoxification Liposomes in enzyme therapy Liposomes in cardiovascular diseases Lecithin and atherosclerosis Liposomes as synthetic erythrocytes Liposomes in the diseases of liver and spleen.

Liposome in the therapy of neonatal jaundice Structure of amphiphilic aggregates 43 Structure 43 Dynamics 52 Part II. Application of liposomes in basic sciences Introduction 6. Applications of liposomes in theoretical sciences 7. Conventional liposomes in the therapy of cancer Anthracyclines File Size: KB.

Applications of liposomes in medicine and pharmacology Applications of lipo somes in medicine and pharmacol- ogy can be divided into diagno stic and therapeutic. Liposomes: Concept and Therapeutic Applications: /ch The science of liposomes has expanded in ambit from bench to clinic through industrial production in thirty years since the naissance of the concept.

ThisCited by: 1. Liposomes: Properties and Therapeutic Applications: /ch This chapter reviews the current progress in liposome based pharmaceuticals with particular emphasis on the carrier design, size, surface properties, drugAuthor: Ljiljana Djekic.

Biotin–avidin linkages are also commonly used in research applications; biotinylated bubbles or liposomes may be linked to a biotinylated antibody through an avidin bridge as in Fig.

Alternatively, Klegerman et al. demonstrated that biotin/avidin technology can be used to form aggregates of therapeutic ELIPs and targeted by: Moreover, these applications exhibit some benefits due to special properties of scaffolds, such as mechanical supporting, 3D structure and therapy functions brought by drug-loaded liposomes, such as anti-cancer, antibacterial, and : Ruoyu Cheng, Ruoyu Cheng, Lili Liu, Yi Xiang, Yong Lu, Lianfu Deng, Hongbo Zhang, Hongbo Zhang, Héld.

Methods for the preparation of liposomes. There are many different methods for the preparation of liposomes.

The choice of the appropriate method depends on several factors: 1) the physicochemical characteristics of the liposome components and those of the drug to be loaded; 2) the toxicity and the concentration of the loaded substance; 3) the type of the medium in which the liposomes Cited by: The development of liposomes as a drug delivery system has fluctuated since its introduction in the late 's by A.D.

Bangham. While academic research of liposomes as a model membrane system has always flourished, as the exponential growth of papers can testify, the application of these findings to medically useful products has gone through several : Hardcover.

magnetic liposomes within the tumor mass is required for impro ving therapeutic efficacy and to reduce therapy -related toxicity (Shido et al., ). In order to incr ease the depo. Liposomes in the treatment of infectious diseases.

Liposomes as immunoadjuvants. Liposomes in anticancer therapy. Liposomes and inflammations. Other medical applications of liposomes. Other administration routes of liposomes. Site specific drug delivery. Part 4 Other Applications of Liposomes: Cosmetic.

From the reviews: “The book provides in-depth descriptions of tumor and gene therapies, focusing on cationic liposomes. The book presents the most seminal studies on the application of liposomes in the pharmaceutical area published over the past two decades. the content provides the reader with a comprehensive overview of the topic and constitutes essential reading for those working.

Liposomes, phospholipid bubbles with a bilayered membrane structure, are considered as promising pharmaceutical carriers for different applications. Currently, liposomes are used experimentally. This review discusses about the liposome components, methods of preparation, drug encapsulation mechanism and the potential therapeutic applications of liposomes in cancer therapy.

NANO REVIEW Open Access Liposome: classification, preparation, and applications Abolfazl Akbarzadeh1*, Rogaie Rezaei-Sadabady1,2, Soodabeh Davaran1, Sang Woo Joo5*, Nosratollah Zarghami1*, Younes Hanifehpour5, Mohammad Samiei3, Mohammad Kouhi4 and Kazem Nejati-Koshki1 Abstract Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were Cited by:   Liposomes, sphere-shaped vesicles consisting of one or more phospholipid bilayers, were first described in the mids.

Today, they are a very useful reproduction, reagent, and tool in various scientific disciplines, including mathematics and theoretical physics, biophysics, chemistry, colloid science, biochemistry, and by: With new targets and evaluation the application of liposomes have been expanded to novel therapeutic concepts in cancer therapy, e.g.

vascular targeting and gene silencing approaches. Further studies on this demonstrate efficacy and safety. It clears that in future, liposomes will complement the therapeutic arsenal for fighting cancer.

REFERENCES. Liposomes are often used to deliver a molecular cargo such as DNA for therapeutic benefit.

The lipids used to form such lipoplexes can be cationic, anionic, neutral, or a mixture thereof. Herein physical packing parameters and specific lipids used for gene delivery will be discussed, with lipids classified according to overall by:   Evaluation of liposomes Physical characterization assay Chemical characteristics Biological characterization Therapeutic application of liposomes List of marketed product Conti   Liposomes, phospholipid bubbles with a bilayered membrane structure, are considered as promising pharmaceutical carriers for different applications.

Currently, liposomes are used experimentally and clinically to deliver various pharmaceuticals including drugs and diagnostic agents as well as genes and related by: Application of Liposomes Nanoparticles in the Treatment of Malaria: A Mini Review. Farouk S Nas 1, Yahaya A 2 and Muhammad Ali 3 *.

1 Department of Biological Science, Bayero University Kano, Nigeria. 2 Department of Biological Science, Kano University of Science and Technology, Nigeria.

3 Department of Biological Science, Federal University Gusau, Nigeria Author: Farouk S Nas, Yahaya A, Muhammad Ali. Szoka FC, Papahadjopoulos D () Liposomes: preparation and characterization.

In: Knight CG (ed) Liposomes: from physical structure to therapeutic application. Elsevier, Amsterdam, pp 51–82 Google ScholarCited by: Abstract. The specificity, homogeneity, and availability of large-batch production of liposomes with natural lipids and synthetic lipids have made them an extremely useful tool for the study of diverse cellular phenomena, as well as in medical by: Rooijen, in Encyclopedia of Immunology (Second Edition), Different liposomes for different applications.

Liposomes can be prepared according to different methods. They may vary in their dimensions, composition (different phospholipids and cholesterol contents), charge (resulting from the charges of the composing phospholipids), and structure (multilamellar liposomes consisting of.

Summary. In living organisms, metabolically active compounds are frequently associated with aggregated phospholipid structures. For example, hydrophilic molecules (e.g., enzymes, hormones, neurotransmitters) can be found inside the cell as the content of phospholipid : Rolf E.

Schubert, Karl-Heinz Schmidt. Numerous applications of liposomes in ophthalmic drug delivery were extensively studied. These carriers have successfully improved the drug bioavailability by controlled and targeted delivery.

In the case of topical application improvement in the precorneal retention, transcorneal permeation, and therapeutic efficacy was achieved by utilizing Cited by: Liposomes are spherical vesicles that contain a bilayered membrane structure composed of natural or synthetic amphiphilic lipid molecules [ 6, 7 ].

Their biocompatible and biodegradable composition, as well as their unique ability to encapsulate both hydrophilic and hydrophobic therapeutic agents make liposomes excellent therapeutic by:   Amphotericin B remains a very important drug for the treatment of fungal infections despite its toxicity.

Encapsulation of amphotericin B into liposomes appears to reduce the toxic effects and to improve the clinical efficacy, allowing higher dosages to be given.

The exact mechanism behind the reduced toxicity is not yet known. Amphotericin B is widely distributed after intravenous Cited by: Generally, the physical stability refers to the preservation of liposome structure characteristics while the chemical stability is related to the change in molecular structure of liposomes (Chrai.

Liposomes, Lipid Bilayers and Model Membranes: From Basic Research to Application describes state-of-the-art research and future directions in the field of membranes, which has evolved from basic studies of the physicochemical properties of amphiphiles to their application in industry and medicine.

Written by leading researchers in their fields Format: Paperback. Evaluation of liposomesEvaluation of liposomes The liposomes prepared by various techniques are to be evaluated for their physical properties, has these influence the behavior of liposomes in vivo.

Physical properties 1. Particle size Both particle size and particle size distribution of liposomes influence their physical stability. A liposome is a spherical vesicle having at least one lipid liposome can be used as a vehicle for administration of nutrients and pharmaceutical drugs.

Liposomes can be prepared by disrupting biological membranes (such as by sonication). Liposomes are most often composed of phospholipids, especially phosphatidylcholine, but may also include other lipids, such as egg.

In vitro utilization of liposomes is now recognized as a powerful tool in many bioscience investigations and their associated clinical studies, e.g., liposomes in drug targeting; liposomes in gene transport across plasma and nuclear membranes; liposomes in enzyme therapy in Format: Hardcover.

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